Dr James (Jim) Allison (PhD) is Regental Professor and Chair of Immunology and Executive Director of Immunotherapy at the MD Anderson Cancer Clinic, University of Texas. He is also a director of the Cancer Research Institute scientific advisory council. His research elucidated the mechanism behind T cell activation and pioneered the first immune checkpoint blocker drug for the treatment of cancer. His work has radically transformed the landscape for cancer treatment, shifting it away from targeting a tumour to instead using the immune system to destroy cancer cells. Dr Allison was jointly awarded the Nobel Prize in Physiology or Medicine for this work in 2018. His current research is focused on improving the utility of checkpoint blockade and identifying new targets to unleash the immune system to eradicate cancer.
Dr Padmanee (Pam) Sharma (MD) is a prominent leader in oncology specialising in kidney, bladder and prostate cancer. She is a professor of Genitourinary Medical Oncology and Immunology in the Division of Cancer Medicine, the T.C. and Jeanette Hsu Endowed Chair in Cell Biology, the Scientific Director of the Immunotherapy Platform and the Co-Director of the Parker Institute for Cancer Immunotherapy at The University of Texas MD Anderson Cancer Center. Dr Sharma’s primary focus is to understand resistant mechanisms within the immune system that impact response. Her research has recently implicated the checkpoint VISTA in inhibiting immune responses in prostate cancer. Since 2005 she has been a principal investigator for many clinical trials launched to improve immunotherapies in oncology.
‘Lytix is thrilled to welcome Pam and Jim become to Lytix as Strategic Advisors as well as members of our Scientific Advisory Board. Jim has a distinguished career studying T cell responses in cancer and is one of the founding fathers of modern immunotherapy trailblazing the success of immune checkpoint inhibitors in the fight against cancer. Pam is internationally renowned both as a physician and scientist striving to resolve the issue of immune therapy resistance. She is leading and a principal investigator on numerous translational programs to elucidate the mechanism of resistance and how to overcome it.
The Lytix Scientific Advisory Board constitutes world class leaders in the field of immune-oncology, and we are honoured that they have offered their support to further the development of our oncolytic peptides with the aim to tackle tumour heterogeneity – an unresolved challenge in cancer treatment. Lytix is currently raising funds for its pivotal programs supported by our advisors in trying to realize this next big breakthrough in cancer immune therapy,’ said Edwin Klumper, CEO Lytix Biopharma AS.
About Lytix Biopharma Scientific Advisory Board:
Lytix Biopharma has worked with exceptional researchers and clinicians in the field of immuno-oncology to jointly develop its first-in-class oncolytic peptide platform and has established a world renowned advisory board comprising Dr Aurelien Marabelle, Dr Laurence Zitvogel, Dr Guido Kroemer, Dr Sandra Demaria, Dr Sudhir Aggarwal and Dr Robert Andtbacka who are now being teamed up by Dr Jim Allison and Dr Pam Sharma.
About Lytix Biopharma:
Based in Oslo, Norway, Lytix Biopharma is a clinical stage biotech company developing novel cancer immunotherapies, an area within cancer therapy that is aimed at activating the patient’s immune system to fight cancer. The Company’s technology is based on pioneering research in “host defence peptides” – the nature’s first line of defence towards foreign pathogens. Lytix Biopharma’s lead product, LTX-315, is a first-in-class oncolytic peptide with the potential to personalize immunotherapy.
LTX-315 is administered intratumorally and works by inducing lysis of intracellular organelles of tumour cells such as mitochondria, thereby unleashing a broad spectra of tumour antigens for T cell responses. LTX-315 effectively kills not only therapy sensitive, but also therapy resistant and stem cell-like tumour cells invoking broad personal T cell responses both in the tumour and blood. Clinical trials have shown an increase in CD8+ T cell infiltration and clinical abscopal effects. The company strategy is to utilise this T cell response as a primer to enhance and boost patient specific and tumour associated antigens as part of an adoptive transfer regimen aiming to tackle tumour heterogeneity.
For more information please contact:
Edwin Klumper, CEO
E-mail: [email protected]
Hamina Patel, CMO
E-mail: [email protected]
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